Computational Genetics Group

计算遗传学研究组

The genetic principle of phenotypic determination

For a long time, we are committed to exploring the principles of genetics that determine human phenotypes from the perspective of the intersection of statistical genetics, population genetics and evolutionary genetics. The influence of population structure on phenotypic genetic association, the evolutionary forces that drive differences in human skin tone groups, and the behavioral and pharmacokinetic aspects of nicotine dependence have been investigated. Now, we're looking at a much broader set of human phenotypes.

Cellular population genetics

With the advent of single cell sequencing and ultra-high sensitivity protein spectrometry, scientists have increasingly recognized the heterogeneity of cell populations at the tissue, organ and even more elaborate levels. In the field of developmental biology and tumor biology, the genetics and differentiation of cell populations are the focus in recent years. And microbiome research has shown that there are inextricably links between the composition of the body surface and internal microbial communities and the health and efficacy of drugs. We are working extensively with multiple research groups at home and abroad to use our leading population genetics research techniques to uncover the patterns of genetic differentiation of cell populations and their relevance to population health.

Evolutionary genetics

Evolution is the fundamental driver of genetic diversity. At the macro level, the entire biosphere is formed; At the microscopic level, it determines the differentiation of the cell population. In collaboration with other research groups, we used advanced experimental methods and innovative data analysis methods to study the effects of genome-wide duplication, that is, the effect after the "Big Bang of genome". In order to understand the first drivers of genomic evolution, and thereby deepen our understanding of areas such as tumor biology.

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